Effects of Caraway and (S)-(+)-carvone Extract on the Expression of Genes Coding Key Glycolytic Enzymes in Streptozotocin-induced Diabetic Rats

Background: Diabetes mellitus is a metabolic disorder causing dysfunctional regulation of carbohydrate metabolism and contributing to multiple serious health challenges worldwide. Aims: This research explores the effect caraway hydroalcoholic extract (S)-(+)-carvone on transcription genes coding for key glycolytic enzymes in liver diabetic rat treated with streptozotocin (STZ). Methods: In this experimental study, diabetes was established four groups rats by injecting 45 mg/kg STZ intraperitoneally. Further normal that were not injected formed control group. Over weeks, effects (150 250 mg/kg) carvone (100 evaluated using PCR histopathological evaluation, specifically form process rats. Results: four-week assessment period, rats’ food intake, therefore blood glucose levels, decreased through daily oral administration when compared those administered further STZ. The expression enzymes, including glucokinase, pyruvate kinase, phosphofructokinase 1 restored near-normal levels extract, especially at 150 dose. Histopathological evaluation demonstrated STZ-induced damage tissue. Conclusion: strongly regulates glycolysis regulating gene